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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well result in a rise in methadone plasma concentrations, which could bring about probably deadly respiratory despair. On top of that, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also lead to a rise in me

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